Google Scholar (Cohen)
2009 – present
Vanderlinden, R.T., Hemmis, C.W., Robinson., Yao, T., and Hill C.P. (2017) “Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism.” J. Biol. Chem. DOI: 10.1074/ jbc.M117.785287
Zhen, C.Y., Tatavosian, R., Huynh, T.N., Duc, H.N., Das, R., Kokotovid, M., Grimm, J.B., Lavis, L.D., Lee, J., Mejia, F.J., Li, Y., Yao, T., Ren, X. (2016) “Live-cell single-molecule tracking revearls co-recognition of H3K27Me3 and DNA targets polycomb Cbx7-PRC1 to chromatin.” Elife, 5: e17667.
Yao, T. (2015) “A Timer to Coordinate Substrate Processing by the 26S Proteasome.” Struct. Mol. Biol. 22: 652-3.
Vanderlinden, R.T., Hemmis, C.W., Schmitt, B., Ndoja, A., Whitby, F.G., Robinson, H., Cohen, R.E., Yao, T.*, and Hill C.P.* (2015) “Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase”. Mol. Cell 57(5):901-11. (*co-corresponding authors).
Choi, Y.-S., Lee, Y.-J., Lee, S.-Y., Shi, L., Ha, J.-H., Cheong, H.-K., Cheong, C., Cohen, R.E., Ryu, K.-S. (2015) “Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 distinguishes their K48-ubiquitylation activities”. J. Biol. Chem. 290:2251-2263.
Muthurajan, U., Hepler, M.R.D., Hieb, A.R., Clark, N.J., Kramer, M., Yao, T., and Luger, K. (2014) “Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone”. Proc. Natl. Acad. Sci. USA 111: 12752-12757.
Long, L., Furgason, M., and Yao, T. (2014) “Non-hydrolyzable ubiquitin-histone mimics”. Methods 70: 134-8.
Ndoja, A., and Yao, T. (2014) “A non-proteolytic function of ubiquitin in transcription repression”. Microb. Cell 1: 253-255.
Long, L., Thelen, J.P., Furgason, M., Haj-Yahya M., Brik A., Cheng, D., Peng, J., and Yao, T. (2014) “The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination”. J. Biol. Chem. 289: 8916-30.
Ndoja, A., Cohen, R.E., and Yao, T. (2014) “Ubiquitin signals proteolysis-independent stripping of transcription factors”. Mol. Cell 53: 893-903.
Nakasone, M.A., Livnat-Levanon, N., Glickman, M.H., Cohen, R.E., Fushman, D. (2013) “Mixed-linkage ubiquitin chains send mixed messages”. Structure 21:727-740.
Sims, J.J., Scavone, F., Cooper, E.M., Kane, L.A., Youle, R.J., Boeke, J.D., and Cohen, R.E. (2012) “Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling”. Nature Methods 9: 303-309.
Ndoja, A., and Yao, T. (2012) “Regulation of gene expression by the ubiquitin-proteasome system”. Semi. Cell Dev. Biol 23: 523-9.
Yao, T. (2013) “Ubiquitin Carboxyl-terminal Hydrolase 37”. Handbook of Proteolytic enzymes
Samara, N.L., Datta, A.B., Berndsen, C.E., Zhang, X., Yao, T., Cohen, R.E., and Wolberger C. (2010) “Structural insights into the assembly and function of the SAGA deubiquitinating module”. Science 328: 1025-9.
Cooper, E.M., Boeke, J.D., Cohen, R.E. (2009) “Specificity of the BRISC deubiquitinating enzyme is not due to selective binding to K63-linked polyubiquitin”. J. Biol. Chem. 285:10344-10352.
Carlile, C.M., Pickart, C.M., Matunis, M.J., and Cohen, R.E. (2009) “Synthesis of free and proliferating nuclear antigen-bound polyubiquitin chains by the RING E3 ubiquitin ligase Rad5”. J. Biol. Chem. 284:29326-29334.
Sims, J.J., Haririnia, H., Dickinson, B., Fushman, D., and Cohen, R.E. (2009) “Avid interactions underlie the K63-linked polyubiquitin binding specificities observed for UBA domains”. Nat. Struct. Mol. Biol. 16:883-889.
Sims, J.J., and Cohen, R.E. (2009) “Linkage-specific avidity defines the lysine 63-linked polyubiquitin binding preference of Rap80”. Mol. Cell 33:775-783.
Cooper, E.M., Cutcliffe, C., Kristiansen, T.Z., Pandey, A., Pickart, C.M., and Cohen, R.E. (2009) “K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1”. EMBO J. 28:621-631.
Wang, T., Yin, L., Cooper, E.M., Lai, M.Y., Dickey, S., Pickart, C.M., Fushman, D., Wilkinson, K.D., Cohen, R.E.*, and Wolberger, C.* (2009) “Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of Otubain 1”. J. Mol. Biol. 386:1011-1023. (*co-corresponding authors).
2002 – 2009
Yao, T., Song, L., Jin, J., Cai, Y., Takahashi, H., Swanson, S.K., Washburn, M.P., Florens, L., Conaway, R.C., Cohen, R.E., and Conaway, J.W. (2008) “Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and the Ino80 chromatin remodeling complex.” Mol. Cell 31: 909-17.
Winborn, B.J., Travis, S.M., Todi, S.V., Scaglione, K.M., Xu, P., Williams, A.J., Cohen, R.E., Peng, J., and Paulson, H.L. (2008) “The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits K63-linkages in mixed linkage ubiquitin chains”. J. Biol. Chem. 283:26436-26443.
Cai, Y., Jin, J., Yao, T., Gottschalk, A.J., Swanson, S.K., Wu, S., Shi, Y., Washburn, M.P., Florens, L., Conaway, R.C., and Conaway, J.W. (2007) “Ubiquitous transcriptional regulator YY1 functions with the human INO80 chromatin remodeler to activate transcription.” Nat. Struct. Mol. Biol. 14: 872-4.
Cai, Y., Jin, J., Gottschalk, A.J., Yao, T., Conaway, J.W., and Conaway, R.C. (2006) “Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes.” Methods 40(4):312-7.
Abmayr, S., Yao, T., Parmely, T., and Workman, J.L. (2006) “Preparation of nuclear and cytoplasmic extracts from mammalian cells.” Curr. Protocols Mol. Biol. Unit 12.1.1-12.1.10
Yao, T., Song, L., Xu, W., DeMartino, G.N., Florens, L., Swanson, S.K., Washburn, M.P., Conaway, R.C., Conaway, J.W., and Cohen, R.E. (2006) “Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.” Nat. Cell Biol. 8: 994-1002.
Yao, T., and Cohen, R.E. (2005) “Ubiquitin-ovomucoid fusion proteins as model substrates for monitoring degradation and deubiquitination by proteasomes.” Methods Enzymol. 398: 522-540.
Jin, J., Cai, Y., Yao, T., Gottschalk, A.J., Florens, L., Swanson, S.K., Gutierrez, J.L., Coleman, M.K., Workman, J.L., Mushegian, A., Washburn, M.P., Conaway, R.C, and Conaway, J.W. (2005) “A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex.” J. Biol. Chem. 280: 41207-41212.
Conaway, R.C., Sato, S., Tomomori-Sato, C., Yao, T., and Conaway, J.W. (2005) “The mammalian Mediator complex and its role in transcriptional regulation.” Trends Biochem. Sci. 30: 250-255.
Conaway, J.W., Florens, L., Sato, S., Tomomori-Sato, C., Parmely, T.J., Yao, T., Swanson, S.K., Banks, C.A., Washburn, M.P., and Conaway, R.C. (2005) “The mammalian Mediator complex.” FEBS Lett. 579: 904-908.
Hu, M., Li, P., Song, L., Jeffrey, P.D., Chenova, T., Wilkinson, K.D., Cohen, R.E., and Shi, Y. (2005) “Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14”. EMBO J. 24: 3747-3756.
Chai, Y, Shoesmith Berke, S., Cohen, R.E., and Paulson, H.L. (2004) “Poly-ubiquitin binding by the polyglutamine disease protein ataxin-3 links its normal function to protein surveillance pathways”. J. Biol. Chem. 279: 3605-3611.
Wicks, S.J., Haros, K, Maillard, M, Song, L, Cohen, R.E., Dijke, P.T., Chantry, A. (2005) “The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling”. Oncogene 24: 8080-8084.
Pashkova, N., Catlett, N.L., Novak, J.L., Wu, G., Lu, R., Cohen, R.E., and Weisman, L.S. (2005) “Myosin V attachment to cargo requires the tight association of two functional sub-domains”. J. Cell Biol., 168: 359-364.
Pickart, C.M., and Cohen, R.E. (2004) “Proteasomes and their kin: proteases in the machine age”. Nat. Rev. Mol. Cell Biol. 5: 177-187.
Chai, Y, Shoesmith Berke, S., Cohen, R.E., and Paulson, H.L. (2004) “Poly-ubiquitin binding by the polyglutamine disease protein ataxin-3 links its normal function to protein surveillance pathways”. J. Biol. Chem. 279: 3605-361134.
Hu, M., Li, P., Li, M., Li, W., Yao, T., Wu, J.W., Gu, W., Cohen, R.E., and Shi, Y. (2002) “Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.” Cell 111: 1041-1054.
Yao, T., and Cohen, R.E. (2002) “A cryptic protease couples deubiquitination and degradation by the proteasome.” Nature 419: 403-407.
1996 – 2002
You, J., Cohen, R.E., and Pickart, C.M. (2001) Update: Construct for high level eukaryotic gene expression and low misincorporation of lysine for arginine during expression of pET-encoded proteins in Escherichia coli. in Cloning and Expression Vectors for Gene Function Analysis (Lu, Q., and Weiner, M.P., eds.), Eaton Publishing, Westborough, MA, pp. 37-41.
Yao, T., and Cohen, R.E. (2000) “Cyclization of polyubiquitin by the E2-25K ubiquitin-conjugating enzyme.” J. Biol. Chem. 275: 36862-36868.
Yao, T., and Cohen, R.E. (1999) “Giant proteases: beyond the proteasome.” Curr. Biol. 9: R551-R553.
You, J., Cohen, R.E., and Pickart, C.M. (1999) “Construct for high level eukaryotic gene expression and low misincorporation of lysine for arginine during expression of pET-encoded proteins in E. coli”. BioTechniques 26: 950-954.
Johnston, S.C., Riddle, S.M., Cohen, R.E.*, and Hill, C.P.* (1999) “Structural basis for the specificity of ubiquitin C-terminal hydrolases”. EMBO J. 18: 3877-3887. (*co-corresponding authors).
Shaeffer, J.R., and Cohen, R.E. (1998) “Enhancement by ubiquitin aldehyde of proteolysis of hemoglobin a-subunits in b-thalassemic hemolysates”. Annals NY Acad. Sci. 850: 394-397.
Lam, Y.A., DeMartino, G.N., Pickart, C.M., and Cohen, R.E. (1997) “Specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of 26 S proteasomes”. J. Biol. Chem. 272: 28438-28446.
Lam, Y.A., Xu , W., DeMartino, G.N., and Cohen, R.E. (1997) “Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome”. Nature 385:737-740.
Shaeffer, J.R., and Cohen, R.E. (1997) “Ubiquitin aldehyde increases the ATP-dependent proteolysis of hemoglobin a-subunits in b-thalassemic hemolysates”. Blood 90:1300-1308.
Piotrowski, J., Beal, R., Hoffman, L., Wilkinson, K.D., Cohen, R.E., and Pickart, C.M. (1997) “Inhibition of the 26 S proteasome by polyubiquitin chains synthesized to have defined lengths”. J. Biol. Chem. 272: 23712-23721.
Shaeffer, J.R., and Cohen, R.E. (1996) “Differential effects of ubiquitin aldehyde on ubiquitin and ATP-dependent protein degradation”. Biochemistry 35:10886-10893.